Drug interactions
Amitriptyline + Carbachol
Severity: Minor
Amitriptyline and Carbachol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist, whereas amitriptyline has antimuscarinic effects that can oppose it. The therapeutic effect of carbachol may be reduced, though the practical impact depends on the route and dose. Ophthalmic or intraocular use has little systemic exposure.
What this interaction means in plain words
Amitriptyline and Carbachol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Carbachol belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism between muscarinic agonism by carbachol and muscarinic blockade by amitriptyline.
What to do
Monitor for reduced cholinergic response such as an inadequate pupillary or bladder effect. Adjust the carbachol dose if the response is diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Amitriptyline with Carbachol?
MediHelp rates the interaction as minor. Amitriptyline and Carbachol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist, whereas amitriptyline has antimuscarinic effects that can oppose it. The therapeutic effect of carbachol may be reduced, though the practical impact depends on the route and dose. Ophthalmic or intraocular use has little systemic exposure.
How serious is the interaction between Amitriptyline and Carbachol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced cholinergic response such as an inadequate pupillary or bladder effect. Adjust the carbachol dose if the response is diminished.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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