Drug interactions
Azelastine + Carbinoxamine
Severity: Moderate
Azelastine and Carbinoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are H1 antihistamines, and carbinoxamine is a sedating first-generation agent. Using them together duplicates therapy and increases drowsiness and anticholinergic effects.
What this interaction means in plain words
Azelastine and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Carbinoxamine belongs to Respiratory.
Why it happens
Duplicate H1 antagonism leading to additive sedation and anticholinergic effects.
What to do
Avoid combining where possible and use a single antihistamine. If both are needed, monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Azelastine with Carbinoxamine?
MediHelp rates the interaction as moderate. Azelastine and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are H1 antihistamines, and carbinoxamine is a sedating first-generation agent. Using them together duplicates therapy and increases drowsiness and anticholinergic effects.
How serious is the interaction between Azelastine and Carbinoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and use a single antihistamine. If both are needed, monitor for sedation and anticholinergic effects.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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