Drug interactions
Amitriptyline + Cariprazine
Severity: Moderate
Amitriptyline and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use may cause additive sedation, dizziness and orthostatic hypotension. Both can also affect cardiac and metabolic parameters.
What this interaction means in plain words
Amitriptyline and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Cariprazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and alpha-adrenergic blocking effects.
What to do
Monitor for sedation and orthostasis, particularly at initiation and after dose increases. Counsel patients on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Amitriptyline with Cariprazine?
MediHelp rates the interaction as moderate. Amitriptyline and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use may cause additive sedation, dizziness and orthostatic hypotension. Both can also affect cardiac and metabolic parameters.
How serious is the interaction between Amitriptyline and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostasis, particularly at initiation and after dose increases. Counsel patients on driving and fall risk.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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