Drug interactions
Amitriptyline + Chlorzoxazone
Severity: Moderate
Amitriptyline and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is strongly sedating and anticholinergic, and combining it with chlorzoxazone can intensify drowsiness and dizziness. This increases the risk of falls and impaired driving, especially in older adults.
What this interaction means in plain words
Amitriptyline and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and anticholinergic effects, and counsel patients about driving. Consider dose reduction of either drug if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Chlorzoxazone?
MediHelp rates the interaction as moderate. Amitriptyline and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is strongly sedating and anticholinergic, and combining it with chlorzoxazone can intensify drowsiness and dizziness. This increases the risk of falls and impaired driving, especially in older adults.
How serious is the interaction between Amitriptyline and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and counsel patients about driving. Consider dose reduction of either drug if sedation is excessive.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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