Drug interactions
Amitriptyline + Cyclizine
Severity: Moderate
Amitriptyline and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic and sedative properties, so combined use can cause drowsiness, dry mouth, constipation, urinary retention, tachycardia and confusion. Older patients are especially vulnerable.
What this interaction means in plain words
Amitriptyline and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and H1-antagonist CNS depression.
What to do
Monitor for anticholinergic toxicity and sedation and use the lowest effective doses. Consider a non-anticholinergic antiemetic in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Amitriptyline with Cyclizine?
MediHelp rates the interaction as moderate. Amitriptyline and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic and sedative properties, so combined use can cause drowsiness, dry mouth, constipation, urinary retention, tachycardia and confusion. Older patients are especially vulnerable.
How serious is the interaction between Amitriptyline and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation and use the lowest effective doses. Consider a non-anticholinergic antiemetic in older patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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