Drug interactions
Amitriptyline + Deutetrabenazine
Severity: Moderate
Amitriptyline and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and each has some QT-prolonging potential. Combined use may increase drowsiness and the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Amitriptyline and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and QT prolongation.
What to do
Obtain an ECG in patients with cardiac risk factors and correct electrolyte abnormalities. Monitor for sedation and depression and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Amitriptyline with Deutetrabenazine?
MediHelp rates the interaction as moderate. Amitriptyline and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and each has some QT-prolonging potential. Combined use may increase drowsiness and the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Amitriptyline and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac risk factors and correct electrolyte abnormalities. Monitor for sedation and depression and adjust doses as needed.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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