Drug interactions
Amitriptyline + Felodipine
Severity: Minor
Amitriptyline and Felodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may inhibit P-glycoprotein, but the clinical effect on amitriptyline exposure is unlikely to be significant. Both drugs can lower blood pressure, with amitriptyline causing orthostatic hypotension, so additive hypotension is possible.
What this interaction means in plain words
Amitriptyline and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Felodipine belongs to Cardiovascular.
Why it happens
Theoretical P-glycoprotein inhibition by felodipine; additive hypotensive effects may also occur.
What to do
No routine adjustment is needed. Monitor for orthostatic hypotension and anticholinergic or sedative effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Felodipine?
MediHelp rates the interaction as minor. Amitriptyline and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine may inhibit P-glycoprotein, but the clinical effect on amitriptyline exposure is unlikely to be significant. Both drugs can lower blood pressure, with amitriptyline causing orthostatic hypotension, so additive hypotension is possible.
How serious is the interaction between Amitriptyline and Felodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for orthostatic hypotension and anticholinergic or sedative effects.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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