Drug interactions
Arsenic trioxide + Fluticasone-vilanterol
Severity: Major
Arsenic trioxide and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide markedly prolongs the QT interval and can cause torsade de pointes. Vilanterol may add to this through beta-agonist effects on heart rate and potassium, raising arrhythmia risk in an already vulnerable patient.
What this interaction means in plain words
Arsenic trioxide and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia and sympathetic stimulation.
What to do
Prefer a non-beta-agonist alternative where possible. If used, monitor ECG and keep potassium and magnesium within normal range throughout arsenic therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Arsenic trioxide and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and can cause torsade de pointes. Vilanterol may add to this through beta-agonist effects on heart rate and potassium, raising arrhythmia risk in an already vulnerable patient.
How serious is the interaction between Arsenic trioxide and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-beta-agonist alternative where possible. If used, monitor ECG and keep potassium and magnesium within normal range throughout arsenic therapy.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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