Drug interactions
Amitriptyline + Gabapentin enacarbil
Severity: Moderate
Amitriptyline and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and their combination can enhance sedation, dizziness and cognitive impairment. Gabapentinoids with other CNS depressants carry a risk of respiratory depression, especially in older adults or patients with respiratory disease.
What this interaction means in plain words
Amitriptyline and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depression through different pharmacologic mechanisms.
What to do
Use the lowest effective doses and titrate slowly. Monitor for sedation and respiratory depression, especially in older patients or those with respiratory impairment or renal dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Gabapentin enacarbil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Amitriptyline with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Amitriptyline and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and their combination can enhance sedation, dizziness and cognitive impairment. Gabapentinoids with other CNS depressants carry a risk of respiratory depression, especially in older adults or patients with respiratory disease.
How serious is the interaction between Amitriptyline and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor for sedation and respiratory depression, especially in older patients or those with respiratory impairment or renal dysfunction.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
