Drug interactions
Amitriptyline + Gilteritinib
Severity: Major
Amitriptyline and Gilteritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, which raises the risk of torsades de pointes. Patients with leukemia often have electrolyte disturbances and other QT-active drugs, adding to the risk.
What this interaction means in plain words
Amitriptyline and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive inhibition of cardiac repolarizing currents causing QTc prolongation.
What to do
Obtain a baseline ECG and monitor it during treatment, correcting potassium and magnesium. Consider an alternative antidepressant if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
- Asenapine + Gilteritinib Major
Frequently asked questions
Can I take Amitriptyline with Gilteritinib?
MediHelp rates the interaction as major. Amitriptyline and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, which raises the risk of torsades de pointes. Patients with leukemia often have electrolyte disturbances and other QT-active drugs, adding to the risk.
How serious is the interaction between Amitriptyline and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment, correcting potassium and magnesium. Consider an alternative antidepressant if QTc becomes prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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