Drug interactions
Amisulpride + Gilteritinib
Severity: Major
Amisulpride and Gilteritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is labeled for QT prolongation and amisulpride also lengthens the QT interval. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive delayed cardiac repolarization via hERG potassium channel effects.
What to do
Avoid the pairing if feasible. If both are necessary, monitor ECG at baseline and regularly and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
- Asenapine + Gilteritinib Major
Frequently asked questions
Can I take Amisulpride with Gilteritinib?
MediHelp rates the interaction as major. Amisulpride and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib is labeled for QT prolongation and amisulpride also lengthens the QT interval. The combination increases the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the pairing if feasible. If both are necessary, monitor ECG at baseline and regularly and keep potassium and magnesium within normal range.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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