Drug interactions
Anagrelide + Gilteritinib
Severity: Major
Anagrelide and Gilteritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval, and anagrelide has a similar effect, so using them together raises the risk of torsades de pointes. Patients with acute myeloid leukemia often have electrolyte disturbances that further raise this risk.
What this interaction means in plain words
Anagrelide and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Gilteritinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Avoid the combination where possible. If it is unavoidable, monitor ECGs and electrolytes and reduce or hold gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Apalutamide + Gilteritinib Major
- Asenapine + Gilteritinib Major
Frequently asked questions
Can I take Anagrelide with Gilteritinib?
MediHelp rates the interaction as major. Anagrelide and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib can prolong the QT interval, and anagrelide has a similar effect, so using them together raises the risk of torsades de pointes. Patients with acute myeloid leukemia often have electrolyte disturbances that further raise this risk.
How serious is the interaction between Anagrelide and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is unavoidable, monitor ECGs and electrolytes and reduce or hold gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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