Drug interactions
Amitriptyline + Iloperidone
Severity: Major
Amitriptyline and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them increases the risk of torsades de pointes. They also add sedation and orthostatic hypotension.
What this interaction means in plain words
Amitriptyline and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade, plus additive CNS depression.
What to do
Avoid the combination if possible, or obtain a baseline ECG and monitor QTc, correcting potassium and magnesium. Avoid other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Anagrelide + Iloperidone Major
- Asenapine + Iloperidone Major
Frequently asked questions
Can I take Amitriptyline with Iloperidone?
MediHelp rates the interaction as major. Amitriptyline and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them increases the risk of torsades de pointes. They also add sedation and orthostatic hypotension.
How serious is the interaction between Amitriptyline and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or obtain a baseline ECG and monitor QTc, correcting potassium and magnesium. Avoid other QT-prolonging drugs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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