Drug interactions
Anagrelide + Iloperidone
Severity: Major
Anagrelide and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval and anagrelide has a similar effect. Combined use may raise the risk of torsades de pointes and sudden cardiac events.
What this interaction means in plain words
Anagrelide and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Choose an antipsychotic with less QT effect if possible. If both are required, check baseline and follow-up ECGs and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Asenapine + Iloperidone Major
Frequently asked questions
Can I take Anagrelide with Iloperidone?
MediHelp rates the interaction as major. Anagrelide and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone prolongs the QT interval and anagrelide has a similar effect. Combined use may raise the risk of torsades de pointes and sudden cardiac events.
How serious is the interaction between Anagrelide and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an antipsychotic with less QT effect if possible. If both are required, check baseline and follow-up ECGs and keep potassium and magnesium normal.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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