Drug interactions
Amisulpride + Iloperidone
Severity: Major
Amisulpride and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, so combined use raises the risk of torsades de pointes and sudden death. Using two antipsychotics also adds extrapyramidal effects and neuroleptic malignant syndrome risk.
What this interaction means in plain words
Amisulpride and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and D2 receptor antagonism.
What to do
Avoid combining; use one antipsychotic where possible. If both are needed, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
- Asenapine + Iloperidone Major
Frequently asked questions
Can I take Amisulpride with Iloperidone?
MediHelp rates the interaction as major. Amisulpride and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QT interval, so combined use raises the risk of torsades de pointes and sudden death. Using two antipsychotics also adds extrapyramidal effects and neuroleptic malignant syndrome risk.
How serious is the interaction between Amisulpride and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use one antipsychotic where possible. If both are needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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