Drug interactions
Amitriptyline + Isoproterenol
Severity: Moderate
Amitriptyline and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can alter responses to sympathomimetics and may increase the risk of tachyarrhythmias with isoproterenol. The interaction is less pronounced than with indirect or norepinephrine-like agents because isoproterenol is not taken up by neuronal reuptake to a major degree.
What this interaction means in plain words
Amitriptyline and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Tricyclic receptor sensitisation and anticholinergic tachycardia add to the chronotropic and arrhythmogenic effects of isoproterenol.
What to do
Monitor heart rate, blood pressure and ECG during isoproterenol infusion and titrate to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Amitriptyline with Isoproterenol?
MediHelp rates the interaction as moderate. Amitriptyline and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics can alter responses to sympathomimetics and may increase the risk of tachyarrhythmias with isoproterenol. The interaction is less pronounced than with indirect or norepinephrine-like agents because isoproterenol is not taken up by neuronal reuptake to a major degree.
How serious is the interaction between Amitriptyline and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during isoproterenol infusion and titrate to the lowest effective dose.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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