Drug interactions
Amitriptyline + Lemborexant
Severity: Moderate
Amitriptyline and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can increase drowsiness and impair next-day alertness and psychomotor performance. The risk of falls and impaired driving is greater in older adults.
What this interaction means in plain words
Amitriptyline and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedating antihistaminic effects of amitriptyline.
What to do
Use the lowest effective dose of each drug and counsel patients about daytime drowsiness and driving. Reduce the lemborexant dose if daytime sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Amitriptyline with Lemborexant?
MediHelp rates the interaction as moderate. Amitriptyline and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can increase drowsiness and impair next-day alertness and psychomotor performance. The risk of falls and impaired driving is greater in older adults.
How serious is the interaction between Amitriptyline and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and counsel patients about daytime drowsiness and driving. Reduce the lemborexant dose if daytime sedation occurs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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