Drug interactions
Amitriptyline + Levetiracetam
Severity: Minor
Amitriptyline and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and psychomotor slowing, so combined use may intensify these effects. No important pharmacokinetic interaction is expected, and the concern is mainly additive CNS effects.
What this interaction means in plain words
Amitriptyline and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel patients about drowsiness and driving, and review sedation after dose changes. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Amitriptyline with Levetiracetam?
MediHelp rates the interaction as minor. Amitriptyline and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence, dizziness and psychomotor slowing, so combined use may intensify these effects. No important pharmacokinetic interaction is expected, and the concern is mainly additive CNS effects.
How serious is the interaction between Amitriptyline and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving, and review sedation after dose changes. Reduce doses if excessive sedation occurs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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