Drug interactions
Amitriptyline + Loxapine
Severity: Moderate
Amitriptyline and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have anticholinergic activity, so combined use increases drowsiness, confusion and anticholinergic effects. Amitriptyline can also raise antipsychotic exposure, and both may lower seizure threshold.
What this interaction means in plain words
Amitriptyline and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and seizure threshold lowering.
What to do
Monitor for sedation, anticholinergic toxicity and seizures, and use the lowest effective doses. Avoid in patients with seizure history or in the elderly where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Amitriptyline with Loxapine?
MediHelp rates the interaction as moderate. Amitriptyline and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have anticholinergic activity, so combined use increases drowsiness, confusion and anticholinergic effects. Amitriptyline can also raise antipsychotic exposure, and both may lower seizure threshold.
How serious is the interaction between Amitriptyline and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic toxicity and seizures, and use the lowest effective doses. Avoid in patients with seizure history or in the elderly where possible.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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