Drug interactions
Amitriptyline + Metaxalone
Severity: Moderate
Amitriptyline and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is sedating and anticholinergic, and metaxalone also causes drowsiness. The combination can produce heightened sedation, dizziness and impaired psychomotor performance, particularly in older adults. Metaxalone also has a rare reported association with serotonin syndrome when combined with serotonergic drugs.
What this interaction means in plain words
Amitriptyline and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from two sedating agents.
What to do
Use the lowest effective doses and monitor for oversedation and falls, especially in elderly patients. Counsel patients on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Metaxalone?
MediHelp rates the interaction as moderate. Amitriptyline and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is sedating and anticholinergic, and metaxalone also causes drowsiness. The combination can produce heightened sedation, dizziness and impaired psychomotor performance, particularly in older adults. Metaxalone also has a rare reported association with serotonin syndrome when combined with serotonergic drugs.
How serious is the interaction between Amitriptyline and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and falls, especially in elderly patients. Counsel patients on avoiding driving and alcohol.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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