Drug interactions
Amitriptyline + Methocarbamol
Severity: Moderate
Amitriptyline and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is a sedating tricyclic antidepressant, and methocarbamol also depresses the central nervous system. Combined use can increase drowsiness, dizziness and psychomotor impairment, and the anticholinergic effects of amitriptyline may add to confusion in older patients.
What this interaction means in plain words
Amitriptyline and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with amitriptyline's antihistaminic and anticholinergic effects contributing.
What to do
Use the lowest effective doses and monitor for oversedation and confusion, especially in older adults. Counsel about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Methocarbamol?
MediHelp rates the interaction as moderate. Amitriptyline and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is a sedating tricyclic antidepressant, and methocarbamol also depresses the central nervous system. Combined use can increase drowsiness, dizziness and psychomotor impairment, and the anticholinergic effects of amitriptyline may add to confusion in older patients.
How serious is the interaction between Amitriptyline and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and confusion, especially in older adults. Counsel about driving and alcohol.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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