Drug interactions
Amitriptyline + Methohexital
Severity: Moderate
Amitriptyline and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic, and amitriptyline adds sedation and can contribute to hypotension and respiratory depression. Tricyclics may also lower the seizure threshold, and methohexital can provoke seizure activity in susceptible patients.
What this interaction means in plain words
Amitriptyline and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible additive effects on the seizure threshold and blood pressure.
What to do
Inform the anesthesia team of amitriptyline use and titrate methohexital carefully with continuous monitoring of respiration, blood pressure and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Amitriptyline with Methohexital?
MediHelp rates the interaction as moderate. Amitriptyline and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic, and amitriptyline adds sedation and can contribute to hypotension and respiratory depression. Tricyclics may also lower the seizure threshold, and methohexital can provoke seizure activity in susceptible patients.
How serious is the interaction between Amitriptyline and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of amitriptyline use and titrate methohexital carefully with continuous monitoring of respiration, blood pressure and ECG.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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