Drug interactions
Amitriptyline + Nicardipine
Severity: Minor
Amitriptyline and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise amitriptyline exposure through transporter or CYP effects, and both can cause hypotension. Anticholinergic effects, sedation and orthostasis may be more pronounced.
What this interaction means in plain words
Amitriptyline and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Possible P-glycoprotein and CYP inhibition by nicardipine reduces amitriptyline clearance; evidence is limited.
What to do
No routine dose change is needed. Monitor for orthostatic hypotension, sedation and anticholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Nicardipine?
MediHelp rates the interaction as minor. Amitriptyline and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may modestly raise amitriptyline exposure through transporter or CYP effects, and both can cause hypotension. Anticholinergic effects, sedation and orthostasis may be more pronounced.
How serious is the interaction between Amitriptyline and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for orthostatic hypotension, sedation and anticholinergic effects.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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