Drug interactions
Amitriptyline + Oxymorphone
Severity: Moderate
Amitriptyline and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can lead to excessive drowsiness, impaired cognition and respiratory depression. Amitriptyline's anticholinergic effects may also worsen opioid-induced constipation and urinary retention.
What this interaction means in plain words
Amitriptyline and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and the sedating and anticholinergic properties of the tricyclic antidepressant.
What to do
Start low and titrate gradually, monitoring sedation and respiratory function. Counsel patients on driving and alcohol, and monitor bowel and bladder function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Oxymorphone?
MediHelp rates the interaction as moderate. Amitriptyline and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can lead to excessive drowsiness, impaired cognition and respiratory depression. Amitriptyline's anticholinergic effects may also worsen opioid-induced constipation and urinary retention.
How serious is the interaction between Amitriptyline and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low and titrate gradually, monitoring sedation and respiratory function. Counsel patients on driving and alcohol, and monitor bowel and bladder function.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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