Drug interactions
Amitriptyline + Quetiapine
Severity: Moderate
Amitriptyline and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and can prolong the QT interval, so combined use increases the risk of excessive sedation, orthostatic hypotension and ventricular arrhythmias. Anticholinergic effects may also be additive.
What this interaction means in plain words
Amitriptyline and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and QT prolongation.
What to do
Use the lowest effective doses, check a baseline ECG and electrolytes, and monitor for sedation and orthostasis. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Amitriptyline with Quetiapine?
MediHelp rates the interaction as moderate. Amitriptyline and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and can prolong the QT interval, so combined use increases the risk of excessive sedation, orthostatic hypotension and ventricular arrhythmias. Anticholinergic effects may also be additive.
How serious is the interaction between Amitriptyline and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, check a baseline ECG and electrolytes, and monitor for sedation and orthostasis. Avoid adding other QT-prolonging drugs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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