Drug interactions
Amitriptyline + Sarecycline
Severity: Minor
Amitriptyline and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may inhibit P-glycoprotein and modestly increase exposure to P-gp substrates. The clinical relevance for amitriptyline is probably small and not well established.
What this interaction means in plain words
Amitriptyline and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak P-glycoprotein inhibition by sarecycline reducing efflux of amitriptyline.
What to do
No dose change is routinely needed; monitor for increased anticholinergic or sedative effects of amitriptyline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Amitriptyline with Sarecycline?
MediHelp rates the interaction as minor. Amitriptyline and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may inhibit P-glycoprotein and modestly increase exposure to P-gp substrates. The clinical relevance for amitriptyline is probably small and not well established.
How serious is the interaction between Amitriptyline and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for increased anticholinergic or sedative effects of amitriptyline.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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