Drug interactions
Amitriptyline + Sitagliptin
Severity: Minor
Amitriptyline and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline may alter glycemic control in diabetic patients. Sitagliptin alone rarely causes hypoglycemia, so the interaction is expected to be small.
What this interaction means in plain words
Amitriptyline and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Sitagliptin belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose; mechanism not well established.
What to do
Monitor glucose when amitriptyline is started or stopped. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Amitriptyline with Sitagliptin?
MediHelp rates the interaction as minor. Amitriptyline and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline may alter glycemic control in diabetic patients. Sitagliptin alone rarely causes hypoglycemia, so the interaction is expected to be small.
How serious is the interaction between Amitriptyline and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when amitriptyline is started or stopped. No routine dose change is needed.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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