Drug interactions
Amitriptyline + Tiotropium
Severity: Moderate
Amitriptyline and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is strongly anticholinergic and can add to the antimuscarinic burden of tiotropium. This may cause dry mouth, urinary retention, constipation, tachycardia, blurred vision and raised intraocular pressure.
What this interaction means in plain words
Amitriptyline and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic symptoms, especially urinary retention and narrow-angle glaucoma risk. Consider a less anticholinergic antidepressant in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Tiotropium?
MediHelp rates the interaction as moderate. Amitriptyline and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is strongly anticholinergic and can add to the antimuscarinic burden of tiotropium. This may cause dry mouth, urinary retention, constipation, tachycardia, blurred vision and raised intraocular pressure.
How serious is the interaction between Amitriptyline and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially urinary retention and narrow-angle glaucoma risk. Consider a less anticholinergic antidepressant in elderly patients.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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