Drug interactions
Amitriptyline + Vemurafenib
Severity: Major
Amitriptyline and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way, and amitriptyline has similar effects. Combined use raises the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Amitriptyline and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation; vemurafenib may also modulate CYP enzymes involved in tricyclic metabolism.
What to do
Avoid if possible. If combined, obtain baseline and periodic ECGs, and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Vemurafenib
- Alfuzosin + Vemurafenib Major
- Amiodarone + Vemurafenib Major
- Amisulpride + Vemurafenib Major
- Anagrelide + Vemurafenib Major
- Apalutamide + Vemurafenib Major
- Asenapine + Vemurafenib Major
Frequently asked questions
Can I take Amitriptyline with Vemurafenib?
MediHelp rates the interaction as major. Amitriptyline and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval in a concentration-dependent way, and amitriptyline has similar effects. Combined use raises the risk of serious ventricular arrhythmias.
How serious is the interaction between Amitriptyline and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If combined, obtain baseline and periodic ECGs, and correct potassium and magnesium abnormalities.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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