Drug interactions
Amisulpride + Vemurafenib
Severity: Major
Amisulpride and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib causes concentration-dependent QT prolongation, and amisulpride also prolongs QT. The combination raises the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Amisulpride and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible. If both are needed, obtain ECG and electrolytes at baseline and periodically, and correct abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Amisulpride with Vemurafenib?
MediHelp rates the interaction as major. Amisulpride and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib causes concentration-dependent QT prolongation, and amisulpride also prolongs QT. The combination raises the risk of serious ventricular arrhythmias.
How serious is the interaction between Amisulpride and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are needed, obtain ECG and electrolytes at baseline and periodically, and correct abnormalities.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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