Drug interactions
Apalutamide + Vemurafenib
Severity: Major
Apalutamide and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce vemurafenib concentrations through CYP3A4 induction, potentially lowering antitumor efficacy.
What this interaction means in plain words
Apalutamide and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Vemurafenib belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, increasing vemurafenib metabolism.
What to do
Avoid strong CYP3A4 inducers with vemurafenib when possible. If unavoidable, monitor tumor response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Apalutamide with Vemurafenib?
MediHelp rates the interaction as major. Apalutamide and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may reduce vemurafenib concentrations through CYP3A4 induction, potentially lowering antitumor efficacy.
How serious is the interaction between Apalutamide and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers with vemurafenib when possible. If unavoidable, monitor tumor response closely.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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