Drug interactions
Amlodipine + Anastrozole
Severity: Minor
Amlodipine and Anastrozole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole is claimed to raise amlodipine levels through CYP3A4 inhibition. In practice anastrozole is at most a very weak inhibitor in vitro and no meaningful clinical effect has been shown. No relevant change in amlodipine effect is expected.
What this interaction means in plain words
Amlodipine and Anastrozole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Anastrozole belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by anastrozole; not established clinically.
What to do
No dose change is needed. Routine blood pressure monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contraindicated
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
Frequently asked questions
Can I take Amlodipine with Anastrozole?
MediHelp rates the interaction as minor. Amlodipine and Anastrozole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anastrozole is claimed to raise amlodipine levels through CYP3A4 inhibition. In practice anastrozole is at most a very weak inhibitor in vitro and no meaningful clinical effect has been shown. No relevant change in amlodipine effect is expected.
How serious is the interaction between Amlodipine and Anastrozole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Routine blood pressure monitoring is sufficient.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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