Drug interactions
Amlodipine + Axitinib
Severity: Minor
Amlodipine and Axitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, but amlodipine is only a weak CYP3A4 inhibitor, so any increase in axitinib exposure is likely small. Axitinib can cause hypertension, so blood pressure control matters.
What this interaction means in plain words
Amlodipine and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Axitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine possibly reducing axitinib metabolism.
What to do
No axitinib dose change is needed. Monitor blood pressure regularly, as is standard for axitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Amlodipine with Axitinib?
MediHelp rates the interaction as minor. Amlodipine and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, but amlodipine is only a weak CYP3A4 inhibitor, so any increase in axitinib exposure is likely small. Axitinib can cause hypertension, so blood pressure control matters.
How serious is the interaction between Amlodipine and Axitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No axitinib dose change is needed. Monitor blood pressure regularly, as is standard for axitinib.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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