Drug interactions
Amlodipine + Cyclosporin
Severity: Moderate
Amlodipine and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine can increase cyclosporine trough levels in some transplant recipients, and cyclosporine may raise amlodipine exposure. This can add to nephrotoxicity, hypotension, edema or gingival overgrowth.
What this interaction means in plain words
Amlodipine and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Cyclosporin belongs to Miscellaneous.
Why it happens
Mutual interference with CYP3A4 metabolism, with amlodipine's effect on cyclosporine not fully established.
What to do
Monitor cyclosporine trough levels and renal function after starting or changing amlodipine, and adjust the cyclosporine dose if needed. Monitor blood pressure and peripheral edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Cyclosporin?
MediHelp rates the interaction as moderate. Amlodipine and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine can increase cyclosporine trough levels in some transplant recipients, and cyclosporine may raise amlodipine exposure. This can add to nephrotoxicity, hypotension, edema or gingival overgrowth.
How serious is the interaction between Amlodipine and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function after starting or changing amlodipine, and adjust the cyclosporine dose if needed. Monitor blood pressure and peripheral edema.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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