Drug interactions
Amlodipine + Dexamethasone
Severity: Minor
Amlodipine and Dexamethasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone induces CYP3A4 and may lower amlodipine concentrations. Corticosteroids can also raise blood pressure through fluid retention. Together these may reduce antihypertensive control.
What this interaction means in plain words
Amlodipine and Dexamethasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Dexamethasone belongs to Endocrine.
Why it happens
Dexamethasone induces CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure during prolonged dexamethasone therapy. Titrate the amlodipine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Amlodipine with Dexamethasone?
MediHelp rates the interaction as minor. Amlodipine and Dexamethasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone induces CYP3A4 and may lower amlodipine concentrations. Corticosteroids can also raise blood pressure through fluid retention. Together these may reduce antihypertensive control.
How serious is the interaction between Amlodipine and Dexamethasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged dexamethasone therapy. Titrate the amlodipine dose if needed.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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