Drug interactions
Amlodipine + Drospirenone
Severity: Minor
Amlodipine and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a clinically relevant CYP3A4 inhibitor, so a meaningful rise in amlodipine levels is not expected. Drospirenone has mild antimineralocorticoid activity and may slightly lower blood pressure. No significant interaction is anticipated.
What this interaction means in plain words
Amlodipine and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Weak theoretical CYP3A4 inhibition; no established clinically relevant mechanism.
What to do
No dose adjustment is needed. Monitor blood pressure as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Drospirenone
Frequently asked questions
Can I take Amlodipine with Drospirenone?
MediHelp rates the interaction as minor. Amlodipine and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a clinically relevant CYP3A4 inhibitor, so a meaningful rise in amlodipine levels is not expected. Drospirenone has mild antimineralocorticoid activity and may slightly lower blood pressure. No significant interaction is anticipated.
How serious is the interaction between Amlodipine and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood pressure as routine.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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