Drug interactions
Amlodipine + Erythromycin
Severity: Moderate
Amlodipine and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can raise amlodipine concentrations, increasing the risk of hypotension, peripheral edema and dizziness. The effect is more notable in older patients.
What this interaction means in plain words
Amlodipine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by erythromycin.
What to do
Monitor blood pressure and edema during the antibiotic course and reduce the amlodipine dose if hypotension occurs. Consider azithromycin as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Erythromycin?
MediHelp rates the interaction as moderate. Amlodipine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can raise amlodipine concentrations, increasing the risk of hypotension, peripheral edema and dizziness. The effect is more notable in older patients.
How serious is the interaction between Amlodipine and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during the antibiotic course and reduce the amlodipine dose if hypotension occurs. Consider azithromycin as an alternative.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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