Drug interactions
Amlodipine + Larotrectinib
Severity: Minor
Amlodipine and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, so it could raise amlodipine exposure slightly. A clinically relevant effect has not been well established.
What this interaction means in plain words
Amlodipine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing amlodipine metabolism.
What to do
No empiric dose change is required; monitor blood pressure and for edema or hypotension after starting larotrectinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Amlodipine with Larotrectinib?
MediHelp rates the interaction as minor. Amlodipine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, so it could raise amlodipine exposure slightly. A clinically relevant effect has not been well established.
How serious is the interaction between Amlodipine and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required; monitor blood pressure and for edema or hypotension after starting larotrectinib.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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