Drug interactions
Amlodipine + Propranolol
Severity: Minor
Amlodipine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with a dihydropyridine calcium channel blocker produces additive blood pressure lowering, which is often used therapeutically. Occasionally it causes excessive hypotension, dizziness or reflex-related effects, particularly at treatment start or dose increases.
What this interaction means in plain words
Amlodipine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects via beta-blockade and arterial vasodilation.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Propranolol?
MediHelp rates the interaction as minor. Amlodipine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a beta-blocker with a dihydropyridine calcium channel blocker produces additive blood pressure lowering, which is often used therapeutically. Occasionally it causes excessive hypotension, dizziness or reflex-related effects, particularly at treatment start or dose increases.
How serious is the interaction between Amlodipine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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