Drug interactions
Amlodipine + Rocuronium
Severity: Minor
Amlodipine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as rocuronium. Clinically this is usually small, but it may mean slower recovery from blockade.
What this interaction means in plain words
Amlodipine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Rocuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce prejunctional acetylcholine release and so add to postsynaptic nicotinic receptor blockade.
What to do
Monitor neuromuscular function with train-of-four and titrate rocuronium to effect. Confirm adequate recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Rocuronium?
MediHelp rates the interaction as minor. Amlodipine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as rocuronium. Clinically this is usually small, but it may mean slower recovery from blockade.
How serious is the interaction between Amlodipine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate rocuronium to effect. Confirm adequate recovery before extubation.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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