Drug interactions
Amlodipine-benazepril + Aripiprazole
Severity: Moderate
Amlodipine-benazepril and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has alpha-1 blocking activity and can cause orthostatic hypotension, which may add to the effect of amlodipine and benazepril. Dizziness and falls are the main concern.
What this interaction means in plain words
Amlodipine-benazepril and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Aripiprazole belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from aripiprazole alpha-1 antagonism and antihypertensive vasodilation.
What to do
Monitor orthostatic blood pressure when starting or increasing aripiprazole and adjust antihypertensives if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Amlodipine-benazepril with Aripiprazole?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole has alpha-1 blocking activity and can cause orthostatic hypotension, which may add to the effect of amlodipine and benazepril. Dizziness and falls are the main concern.
How serious is the interaction between Amlodipine-benazepril and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or increasing aripiprazole and adjust antihypertensives if symptomatic.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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