Drug interactions
Amlodipine-benazepril + Chloramphenicol
Severity: Minor
Amlodipine-benazepril and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and could raise amlodipine concentrations, causing excess vasodilation with hypotension and edema. Clinical data are scarce, and the effect is predicted from the mechanism.
What this interaction means in plain words
Amlodipine-benazepril and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of amlodipine may increase its exposure.
What to do
Monitor blood pressure and for peripheral edema while chloramphenicol is given. Reduce the amlodipine dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amlodipine-benazepril with Chloramphenicol?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol inhibits CYP3A4 and could raise amlodipine concentrations, causing excess vasodilation with hypotension and edema. Clinical data are scarce, and the effect is predicted from the mechanism.
How serious is the interaction between Amlodipine-benazepril and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for peripheral edema while chloramphenicol is given. Reduce the amlodipine dose if hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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