Drug interactions
Amlodipine-benazepril + Diazoxide
Severity: Moderate
Amlodipine-benazepril and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide is a potent vasodilator and may enhance the blood pressure lowering of other antihypertensives. Significant hypotension can occur when it is combined with amlodipine and benazepril.
What this interaction means in plain words
Amlodipine-benazepril and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive vasodilation through potassium channel opening by diazoxide combined with calcium channel blockade and ACE inhibition.
What to do
Monitor blood pressure closely when diazoxide is started or adjusted. Reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Amlodipine-benazepril with Diazoxide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazoxide is a potent vasodilator and may enhance the blood pressure lowering of other antihypertensives. Significant hypotension can occur when it is combined with amlodipine and benazepril.
How serious is the interaction between Amlodipine-benazepril and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when diazoxide is started or adjusted. Reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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