Drug interactions
Amlodipine-benazepril + Diflunisal
Severity: Moderate
Amlodipine-benazepril and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors. In volume-depleted, elderly or renally impaired patients the combination can cause acute kidney injury, and hyperkalemia may also occur.
What this interaction means in plain words
Amlodipine-benazepril and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces vasodilation of the afferent arteriole and promotes sodium and water retention, opposing ACE inhibitor effects.
What to do
Use the shortest NSAID course at the lowest dose, ensure adequate hydration, and monitor blood pressure, creatinine and potassium. Prefer paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Amlodipine-benazepril with Diflunisal?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors. In volume-depleted, elderly or renally impaired patients the combination can cause acute kidney injury, and hyperkalemia may also occur.
How serious is the interaction between Amlodipine-benazepril and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest NSAID course at the lowest dose, ensure adequate hydration, and monitor blood pressure, creatinine and potassium. Prefer paracetamol where suitable.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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