Drug interactions
Amlodipine-benazepril + Glyburide
Severity: Minor
Amlodipine-benazepril and Glyburide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally enhance the glucose-lowering effect of sulfonylureas, leading to hypoglycemia.
What this interaction means in plain words
Amlodipine-benazepril and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Glyburide belongs to Endocrine.
Why it happens
ACE inhibitors may increase insulin sensitivity, adding to sulfonylurea effects.
What to do
Monitor blood glucose when starting the ACE inhibitor and educate patients on hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Amlodipine-benazepril with Glyburide?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and occasionally enhance the glucose-lowering effect of sulfonylureas, leading to hypoglycemia.
How serious is the interaction between Amlodipine-benazepril and Glyburide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting the ACE inhibitor and educate patients on hypoglycemia symptoms.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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