Drug interactions
Amlodipine-benazepril + Indomethacin
Severity: Moderate
Amlodipine-benazepril and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the antihypertensive effect of ACE inhibitors and impair renal function. The risk is highest in older patients, those who are volume depleted, or with existing renal impairment.
What this interaction means in plain words
Amlodipine-benazepril and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces renal vasodilation and sodium excretion, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Use the lowest effective dose for the shortest time, and ensure adequate hydration. Monitor blood pressure and serum creatinine and potassium, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Amlodipine-benazepril with Indomethacin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the antihypertensive effect of ACE inhibitors and impair renal function. The risk is highest in older patients, those who are volume depleted, or with existing renal impairment.
How serious is the interaction between Amlodipine-benazepril and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time, and ensure adequate hydration. Monitor blood pressure and serum creatinine and potassium, or choose an alternative analgesic.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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