Drug interactions
Amlodipine-benazepril + Lenacapavir
Severity: Moderate
Amlodipine-benazepril and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase amlodipine concentrations. This may cause more hypotension, dizziness and peripheral edema, and the effect may persist for months after subcutaneous dosing.
What this interaction means in plain words
Amlodipine-benazepril and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by lenacapavir reduces amlodipine metabolism.
What to do
Monitor blood pressure and edema, and reduce the amlodipine dose if adverse effects appear. Continue monitoring for an extended period after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Lenacapavir?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase amlodipine concentrations. This may cause more hypotension, dizziness and peripheral edema, and the effect may persist for months after subcutaneous dosing.
How serious is the interaction between Amlodipine-benazepril and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the amlodipine dose if adverse effects appear. Continue monitoring for an extended period after the last lenacapavir injection.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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