Drug interactions
Amlodipine-benazepril + Lesinurad
Severity: Minor
Amlodipine-benazepril and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and could lower amlodipine exposure, potentially reducing blood pressure control. The clinical effect is expected to be small.
What this interaction means in plain words
Amlodipine-benazepril and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Lesinurad belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 increases amlodipine metabolism.
What to do
Check blood pressure after starting or stopping lesinurad. Adjust the amlodipine dose only if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Lesinurad?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is a weak CYP3A inducer and could lower amlodipine exposure, potentially reducing blood pressure control. The clinical effect is expected to be small.
How serious is the interaction between Amlodipine-benazepril and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure after starting or stopping lesinurad. Adjust the amlodipine dose only if control is lost.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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