Drug interactions
Amlodipine-benazepril + Nicardipine
Severity: Moderate
Amlodipine-benazepril and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two dihydropyridine calcium channel blockers have the same mechanism, so combining them adds little benefit and increases hypotension, edema, flushing and reflex tachycardia. Nicardipine may also modestly inhibit CYP3A4.
What this interaction means in plain words
Amlodipine-benazepril and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade with additive vasodilation.
What to do
Avoid therapeutic duplication; use one dihydropyridine and, if needed, add an agent from another class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-benazepril with Nicardipine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two dihydropyridine calcium channel blockers have the same mechanism, so combining them adds little benefit and increases hypotension, edema, flushing and reflex tachycardia. Nicardipine may also modestly inhibit CYP3A4.
How serious is the interaction between Amlodipine-benazepril and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication; use one dihydropyridine and, if needed, add an agent from another class.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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