Drug interactions
Amlodipine-benazepril + Probenecid
Severity: Minor
Amlodipine-benazepril and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may reduce renal tubular secretion of benazeprilat, increasing exposure to the ACE inhibitor. This may produce greater blood pressure lowering or other dose-related effects.
What this interaction means in plain words
Amlodipine-benazepril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Inhibition of renal organic anion transport reduces tubular secretion of benazepril and its active metabolite.
What to do
Monitor blood pressure and renal function when probenecid is started or stopped. Reduce the benazepril dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Amlodipine-benazepril with Probenecid?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid may reduce renal tubular secretion of benazeprilat, increasing exposure to the ACE inhibitor. This may produce greater blood pressure lowering or other dose-related effects.
How serious is the interaction between Amlodipine-benazepril and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when probenecid is started or stopped. Reduce the benazepril dose if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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